Study on the role of \(\textit{TDRD1}\) variants in male infertility among 310 Vietnamese individuals

Infertility is a global reproductive health burden affected by various genetic factors, including spermatogenic defects. The instability of the germ cells’ genome caused unregulated replication transposable elements one causes impairment. Tudor domain-containing 1 (TDRD1) expressed only in cells plays significant role piRNA (PIWI-interacting RNA) pathway to maintain integrity via suppressing transposon during spermatogenesis. Despite protein’s male germline development, TDRD1 has not been studied intensively. In this study, we established relationship between infertility and single nucleotide polymorphisms (SNPs) (rs541192490, rs77559927) among 310 Vietnamese men (160 infertile patients 150 healthy controls). Genotypes gene were identified using PCR-RFLP method. results showed that SNPs associated with all three test models (additive, dominant, recessive) (p-value > 0.05). Haplotype analysis two also similar findings. This study would contribute knowledge TDRD1’s association population.